PDLLA · Hyaluronic acid · Collagen stimulator

Juvelook Singapore

PDLLA microspheres carried in hyaluronic acid

Juvelook sits between a skin booster and a volumising filler. Collagen builds over months, and results vary from person to person.

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In Brief

Juvelook treatment in Singapore combines PDLLA microspheres with non-cross-linked hyaluronic acid. It suits skin-quality and fine-texture concerns, while Juvelook Volume addresses deeper contour. Collagen builds over months, and results vary. It cannot lift sagging skin, and it cannot be fully dissolved once placed.

At a Glance: Juvelook Singapore

What it isPDLLA microspheres combined with non-cross-linked hyaluronic acid.
Device or productJuvelook and Juvelook Volume, made by VAIM Co., Ltd. in Korea.
Used forSkin quality and fine texture; Juvelook Volume addresses deeper contour.
Not suited toKnown allergy to a component, or a tendency to keloids or raised scarring.
What it cannot doJuvelook cannot lift sagging skin or be fully dissolved once placed.
Main risksSwelling, bruising, tenderness and small bumps; nodules can occur with any collagen stimulator.

What the Research Shows: Juvelook Singapore

  • A 2015 expert consensus, not a trial, recommended at least 200 U of hyaluronidase, more if no improvement within 60 minutes, and said early treatment within 24 hours usually gave better outcomes. [3]
  • A 2026 randomised assessor-blinded trial of 448 adults reported greater skin hydration with non-cross-linked hyaluronic acid than no treatment at all post-treatment points (P<0.001), with no serious adverse events. [4]
  • A 2024 systematic review of 11 trials reported mild-to-moderate events including nodules; five trials had high risk of bias and authors rated the evidence low quality. [7]
  • A 2026 Chinese double-blind randomized trial of 252 adults reported 92.4% nasolabial fold correction with PLLA versus 59.3% with hyaluronic acid at 48 weeks; erythema occurred in 93.7% with PLLA versus 80.8% with HA. [8]

Figures describe published study groups, which may have used other devices or protocols. They do not predict your result. Updated 3 November 2026.

About This Treatment

What Juvelook is

Juvelook is made by VAIM Co., Ltd. in Korea. The manufacturer classes it as a disposable medical device for temporary improvement of facial wrinkles in adults. It contains poly-D,L-lactic acid, or PDLLA, in non-cross-linked hyaluronic acid. The powder is reconstituted before injection.

The first question is whether your concern is skin quality, volume or laxity. Juvelook may help the first two. It is not a lifting treatment. Dr Sin Yong makes this assessment himself, and he also manages excess Juvelook placed elsewhere.

The two products

Juvelook, 50 mg vial

Contains 42.5 mg PDLLA and 7.5 mg hyaluronic acid. Used for skin quality, fine lines and texture.

Juvelook Volume, 200 mg vial

Contains 170 mg PDLLA and 30 mg hyaluronic acid, and is sold internationally as Lenisna. Used for deeper volume and contour.

How Juvelook treatment in Singapore works

The hyaluronic acid gives hydration on the day. The PDLLA then prompts your skin to build its own collagen over the following months. The particles are spherical, partly porous and amorphous, with a mean size of about 30 µm. Sculptra particles are different: sheet-like, about 50 µm and semi-crystalline. Juvelook uses hyaluronic acid as its carrier, while Sculptra uses carboxymethylcellulose. This is why it is described as a collagen stimulator, and why the change arrives slowly.

Who it suits

Skin quality

Concerns about skin quality or fine texture.

Volume

Volume concerns where structure is the aim, using Juvelook Volume.

Sagging skin

If sagging is your main concern, Juvelook is the wrong tool. The consultation will separate this from a skin-quality or volume concern.

What has been studied

PDLLA has been studied in the nasolabial folds and the tear trough. A 2026 prospective series of 20 patients with nasolabial folds reported improvement at three months, with no nodules or granulomas. A 2025 study in Korean women reported tear trough improvement without severe complications. A 2026 consensus addressed safe injection technique and visual complications for the higher-concentration product. Published follow-up is short, so these findings cannot predict your result. Juvelook can be used under the eyes, yet the clinic prefers energy-based care there: FSX Laser for skin, and the Restore arm of the VF Lift for hollow areas.

Who should avoid it or wait

Wait

Pregnancy or breastfeeding, and active infection or inflammation in the area, including an acne flare or cold sore.

Avoid

Known allergy to a component, or a tendency to keloids or raised scarring.

Assessed first

Earlier filler or collagen stimulator of unknown type, with ultrasound where needed.

Poor fit

Sagging as the main concern, or wanting a fully reversible result.

What Juvelook cannot do

Lift sagging

Laxity is a lifting problem and needs a different approach.

Fully dissolve

Hyaluronidase breaks down the hyaluronic acid carrier, but not the PDLLA.

Match Sculptra on proof

No randomised trial comparing them has been published.

Promise a duration

No duration is promised, and published follow-up is short.

Risks and side effects

Swelling, bruising, tenderness and small bumps at injection points are expected and settle. Nodules can occur with any collagen stimulator. One case report described non-inflammatory tear-trough nodules about three weeks after PDLLA, which resolved with an energy-based device. The serious risk is vascular occlusion, where product enters a blood vessel. The clinic also manages excess Juvelook that was placed elsewhere. If you have had any earlier filler or collagen stimulator, please say so, as it is assessed first.

Warning signs after injection

Vision change or eye pain

Call 995 now.

Pale, dusky or mottled skin, or worsening pain

You need urgent assessment by the injecting doctor or at A&E.

A red, hot or painful lump

See a doctor the same day, or go to A&E if none is available.

Sessions and fees

Session numbers are not published. Placement, dilution and the number of sessions are set after examination. Fees are not published either. They depend on whether the concern is skin quality or volume, the areas treated, dilution and placement, and any earlier filler needing attention first. A written plan with fee factors follows your consultation. Please ask about aftercare at that visit, so that you know what to expect.

Frequently Asked Questions

Juvelook is used for skin quality, fine lines and texture. Juvelook Volume is used for deeper volume and contour. Results vary.
It sits between the two. The hyaluronic acid gives hydration on the day, and the PDLLA prompts collagen over the following months.
It uses PDLLA in hyaluronic acid, while Sculptra uses PLLA in carboxymethylcellulose. The particles also differ. No randomised trial has compared them.
Collagen builds over months. In one series of 20 patients with nasolabial folds, improvement was reported at three months.
No duration is promised. Published follow-up is short, so a firm figure cannot be given.
Only in part. Hyaluronidase breaks down the hyaluronic acid carrier but not the PDLLA.
No. Sagging is a lifting problem, and your plan would need a different approach.
This is decided after examination, along with placement and dilution. Session counts are not published.
It can, and PDLLA has been studied in the tear trough. The clinic prefers energy-based treatment in this area, and a case report describes nodules there.
SY
Dr Sin Yong
MBBS (NUS) · MRCS (Edinburgh)
MSc Aesthetic Medicine (QMUL) · MSc Practical Dermatology (Cardiff)
Aesthetic physician registered with the Singapore Medical Council.

Juvelook Consultation

Dr Sin Yong will examine you, explain your options and give any fee in writing.

WhatsApp the Clinic

References

  1. Ghatge AS, Ghatge SB The Effectiveness of Injectable Hyaluronic Acid in the Improvement of the Facial Skin Quality: A Systematic Review. Clin Cosmet Investig Dermatol. 2023;16:891-899. View source · DOI
  2. Schelke LW, et al. Ultrasound-Guided Targeted vs Regional Flooding: A Comparative Study for Improving the Clinical Outcome in Soft Tissue Filler Vascular Adverse Event Management. Aesthet Surg J. 2023;43(1):86-96. View source · DOI · PMID 35951759
  3. Cohen JL, et al. Treatment of Hyaluronic Acid Filler-Induced Impending Necrosis With Hyaluronidase: Consensus Recommendations. Aesthet Surg J. 2015;35(7):844-849. View source · DOI · PMID 25964629
  4. Cheng H, et al. A Prospective, Multicenter, Randomized, Assessor-Blinded Study Assessing the Efficacy and Safety of Injectable Non-Cross-Linked Hyaluronic Acid for Improving Facial Skin Rejuvenation. Clin Cosmet Investig Dermatol. 2026;19:1-10 (article 590699). View source · DOI
  5. Urso SU, et al. Use of Minimal Amounts of Hyaluronidase in the Ultrasound-Guided Treatment of Acute Vascular Occlusion by Hyaluronic Acid: A Preliminary Report. Aesthet Surg J Open Forum. 2024;6:ojae025. View source · DOI · PMID 38938923
  6. Goodman GJ, et al. A Consensus on Minimizing the Risk of Hyaluronic Acid Embolic Visual Loss and Suggestions for Immediate Bedside Management. Aesthet Surg J. 2020;40(9):1009-1021. View source · DOI · PMID 31693068
  7. Signori R, Barbosa AP, Cezar-dos-Santos F, Carbone AC, Ventura S, Nobre BBS, Neves MLBB, Câmara-Souza MB, Poluha RL, De la Torre Canales G Efficacy and Safety of Poly-l-Lactic Acid in Facial Aesthetics: A Systematic Review. Polymers (Basel). 2024;16(18):2564. View source · DOI · PMID 39339028
  8. Wang Z, Ting W, Zhao H, Huang L, Ma J, Liu H, Liang Y, Shu M, Jin L, Yu N, Long X Long-Term Correction of Nasolabial Folds Using Poly-L-Lactic Acid Microspheres: A Multicenter, Double-Blinded, Randomized Trial. Aesthet Surg J Open Forum. 2026;8:ojag001. View source · DOI · PMID 41694326

Studies may involve other devices or protocols, and they do not predict your own result. See our evidence library and editorial policy.

Related Treatments

Last updated 3 November 2026. General information only. Results vary between individuals. Images are illustrative and do not show patients.